Akari Therapeutics confirme son engagement \u00e0 faire avancer la recherche sur le PH1, une nouvelle mol\u00e9cule modulant l’\u00e9pissage des ARN, utilis\u00e9e dans ses anticorps conjugu\u00e9s (ADCs). Cette approche pourrait offrir une nouvelle solution contre les cancers li\u00e9s \u00e0 des mutations g\u00e9n\u00e9tiques favorisant la croissance tumorale. Le PH1 agit en modifiant l’\u00e9pissage de l’ARN, ce qui provoque la mort des cellules canc\u00e9reuses et active le syst\u00e8me immunitaire. Il cr\u00e9e des prot\u00e9ines mal \u00e9piss\u00e9es, d\u00e9clenchant une r\u00e9ponse immunitaire contre les tumeurs dans tout le corps. La mol\u00e9cule est con\u00e7ue pour \u00eatre lib\u00e9r\u00e9e uniquement dans les cellules canc\u00e9reuses, r\u00e9duisant ainsi les effets secondaires. Elle r\u00e9siste aussi aux m\u00e9canismes de r\u00e9sistance courants dans les traitements contre le cancer. Akari d\u00e9veloppe plusieurs candidats m\u00e9dicaments ciblant notamment la prot\u00e9ine Trop2 et un autre antig\u00e8ne non divulgu\u00e9. L’entreprise \u00e9tudie \u00e9galement la capacit\u00e9 du PH1 \u00e0 perturber des mutations canc\u00e9reuses comme KRAS, BRAF et FGFR3. Abizer Gaslightwala, PDG d’Akari Therapeutics, d\u00e9clare : \u00ab Nous sommes enthousiastes \u00e0 l’id\u00e9e de poursuivre nos recherches sur le PH1, dont les propri\u00e9t\u00e9s ont d\u00e9j\u00e0 \u00e9t\u00e9 d\u00e9montr\u00e9es. \u00bb Il ajoute : \u00ab Nous avons aussi montr\u00e9 que cette mol\u00e9cule peut tuer des cellules canc\u00e9reuses influenc\u00e9es par des mutations comme KRAS, BRAF et FGFR3. Nous continuons \u00e0 explorer son potentiel contre d’autres mutations importantes dans les tumeurs. \u00bb Des r\u00e9sultats pr\u00e9liminaires d’\u00e9tudes pr\u00e9cliniques sur l’activit\u00e9 du PH1 contre une mutation sp\u00e9cifique \u00e0 un type de tumeur majeur sont attendus avant la fin de l’ann\u00e9e. Akari esp\u00e8re utiliser ces donn\u00e9es pour am\u00e9liorer ses traitements contre le cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"
Akari Therapeutics confirme son engagement \u00e0 faire avancer la recherche sur le PH1, une nouvelle mol\u00e9cule modulant l’\u00e9pissage des ARN, utilis\u00e9e dans ses anticorps conjugu\u00e9s (ADCs). Cette approche pourrait offrir une nouvelle solution contre les cancers li\u00e9s \u00e0 des mutations g\u00e9n\u00e9tiques favorisant la croissance tumorale. Le PH1 agit en modifiant l’\u00e9pissage de l’ARN, ce qui […]<\/p>\n","protected":false},"author":1,"featured_media":69707,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[684],"tags":[],"class_list":["post-69706","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nouvelles-pharmaceutiques"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69706","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=69706"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69706\/revisions"}],"predecessor-version":[{"id":69724,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69706\/revisions\/69724"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media\/69707"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=69706"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=69706"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=69706"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}