Apnimed, une entreprise biotechnologique bas\u00e9e dans le Massachusetts, a annonc\u00e9 que son m\u00e9dicament exp\u00e9rimental contre l’apn\u00e9e du sommeil obstructive a atteint ses objectifs principaux lors de l’essai de phase III LunAIRo. Ces r\u00e9sultats encourageants renforcent leur engagement \u00e0 soumettre une demande d’autorisation de mise sur le march\u00e9 (NDA) \u00e0 la FDA d’ici d\u00e9but 2026. L’essai a d\u00e9montr\u00e9 que le m\u00e9dicament AD109 r\u00e9duit la s\u00e9v\u00e9rit\u00e9 des sympt\u00f4mes de 46,8 % en moyenne, mesur\u00e9 par l’indice d’apn\u00e9e-hypopn\u00e9e (IAH), contre seulement 6,8 % pour le placebo. De plus, 51,2 % des patients ont vu leur cat\u00e9gorie de s\u00e9v\u00e9rit\u00e9 diminuer apr\u00e8s le traitement. Ces r\u00e9sultats s’ajoutent \u00e0 ceux de l’essai SynAIRgy, qui a montr\u00e9 une r\u00e9duction moyenne de l’IAH de 55,6 %. Si approuv\u00e9, AD109 serait le premier m\u00e9dicament de ce type, agissant sur la cause profonde de l’apn\u00e9e du sommeil en renfor\u00e7ant les muscles de la voie respiratoire sup\u00e9rieure. Cela pourrait offrir une alternative aux m\u00e9thodes traditionnelles comme la ventilation en pression positive continue (CPAP), qui ne conviennent pas \u00e0 tous les patients. L’apn\u00e9e du sommeil obstructive touche environ 936 millions de personnes dans le monde, et le march\u00e9 des dispositifs m\u00e9dicaux pour son traitement a g\u00e9n\u00e9r\u00e9 3,7 milliards de dollars en 2020. Cependant, les options th\u00e9rapeutiques ont peu \u00e9volu\u00e9 ces derni\u00e8res ann\u00e9es, avec des recommandations souvent limit\u00e9es \u00e0 la perte de poids ou \u00e0 la CPAP. Le seul m\u00e9dicament actuellement disponible, Zepbound de Eli Lilly, est r\u00e9serv\u00e9 aux patients ob\u00e8ses. Selon une \u00e9tude de 2024, seulement 37 % des personnes atteintes d’apn\u00e9e du sommeil sont cliniquement ob\u00e8ses, soulignant le besoin urgent de solutions alternatives. ‘La majorit\u00e9 des 80 millions d’adultes am\u00e9ricains atteints d’apn\u00e9e du sommeil ne sont pas trait\u00e9s, ce qui montre un besoin non satisfait important’, a d\u00e9clar\u00e9 Larry Miller, PDG d’Apnimed. ‘Nous pensons qu’AD109, un m\u00e9dicament oral \u00e0 prise quotidienne pour tous les groupes de poids, pourrait transformer le traitement de l’apn\u00e9e du sommeil et repr\u00e9senter une opportunit\u00e9 commerciale significative pour Apnimed.’<\/p>\n","protected":false},"excerpt":{"rendered":"
Apnimed, une entreprise biotechnologique bas\u00e9e dans le Massachusetts, a annonc\u00e9 que son m\u00e9dicament exp\u00e9rimental contre l’apn\u00e9e du sommeil obstructive a atteint ses objectifs principaux lors de l’essai de phase III LunAIRo. Ces r\u00e9sultats encourageants renforcent leur engagement \u00e0 soumettre une demande d’autorisation de mise sur le march\u00e9 (NDA) \u00e0 la FDA d’ici d\u00e9but 2026. L’essai […]<\/p>\n","protected":false},"author":1,"featured_media":69705,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[684],"tags":[],"class_list":["post-69704","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nouvelles-pharmaceutiques"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69704","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=69704"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69704\/revisions"}],"predecessor-version":[{"id":69723,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69704\/revisions\/69723"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media\/69705"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=69704"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=69704"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=69704"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}