BiomX a publi\u00e9 des r\u00e9sultats prometteurs d’un essai clinique de phase 1b\/2a dans la revue Nature Communications, d\u00e9montrant que leur cocktail de phages BX004 a significativement r\u00e9duit les niveaux bact\u00e9riens chez des patients atteints de mucoviscidose (CF) et d’infections \u00e0 Pseudomonas aeruginosa r\u00e9sistantes aux antibiotiques.<\/p>\n
L’\u00e9tude a r\u00e9v\u00e9l\u00e9 une r\u00e9duction bact\u00e9rienne de 2,7 log\u2081\u2080, soit environ 500 fois plus importante que celle observ\u00e9e avec un placebo, marquant une avanc\u00e9e majeure pour la th\u00e9rapie par phages dans les affections respiratoires chroniques.<\/p>\n
Il est important de noter que l’essai n’a pas montr\u00e9 d’\u00e9mergence de r\u00e9sistance bact\u00e9rienne \u00e0 BX004 et a d\u00e9montr\u00e9 la pr\u00e9servation du microbiome sain, abordant ainsi les limitations cl\u00e9s des antibiotiques traditionnels chez ce groupe de patients.<\/p>\n
La publication valide la plateforme de th\u00e9rapie par phages de BiomX, qui utilise des bact\u00e9riophages naturels et modifi\u00e9s pour cibler les bact\u00e9ries pathog\u00e8nes. Le BX004 a \u00e9t\u00e9 administr\u00e9 par n\u00e9bulisation au cours de l’\u00e9tude.<\/p>\n
Jonathan Solomon, PDG de BiomX, a d\u00e9clar\u00e9 : \u00ab La publication de nos r\u00e9sultats \u00e9valu\u00e9s par des pairs dans une revue de recherche prestigieuse, y compris de nouvelles donn\u00e9es montrant l’activit\u00e9 antimicrobienne de BX004, apporte une validation significative par des tiers de notre plateforme de th\u00e9rapie par phages pour traiter les patients atteints d’infections chroniques \u00e0 P. aeruginosa dans la mucoviscidose. \u00bb<\/p>\n
BiomX a d\u00e9j\u00e0 lanc\u00e9 un essai de phase 2b de BX004, avec des r\u00e9sultats principaux attendus au premier trimestre 2026.<\/p>\n
Rotem Sorek, professeur de g\u00e9n\u00e9tique \u00e0 l’Institut Weizmann des Sciences, a d\u00e9clar\u00e9 : \u00ab En combinant des m\u00e9thodes exp\u00e9rimentales et computationnelles, nous avons d\u00e9velopp\u00e9 une approche de conception qui \u00e9largit la couverture des souches bact\u00e9riennes, r\u00e9duit la probabilit\u00e9 de r\u00e9sistance et am\u00e9liore l’activit\u00e9 contre les biofilms bact\u00e9riens, \u00e9tablissant un cadre efficace pour la conception de th\u00e9rapeutiques \u00e0 base de bact\u00e9riophages de nouvelle g\u00e9n\u00e9ration. \u00bb<\/p>\n
Les donn\u00e9es \u00e9valu\u00e9es par des pairs, tir\u00e9es du premier essai humain de BX004, ajoutent de l’\u00e9lan \u00e0 l’utilisation de la th\u00e9rapie par phages dans le traitement des infections r\u00e9sistantes aux antibiotiques o\u00f9 les options de traitement sont limit\u00e9es.<\/p>\n","protected":false},"excerpt":{"rendered":"
BiomX a publi\u00e9 des r\u00e9sultats prometteurs d’un essai clinique de phase 1b\/2a dans la revue Nature Communications, d\u00e9montrant que leur cocktail de phages BX004 a significativement r\u00e9duit les niveaux bact\u00e9riens chez des patients atteints de mucoviscidose (CF) et d’infections \u00e0 Pseudomonas aeruginosa r\u00e9sistantes aux antibiotiques. L’\u00e9tude a r\u00e9v\u00e9l\u00e9 une r\u00e9duction bact\u00e9rienne de 2,7 log\u2081\u2080, soit […]<\/p>\n","protected":false},"author":1,"featured_media":69694,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[684],"tags":[],"class_list":["post-69693","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nouvelles-pharmaceutiques"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=69693"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69693\/revisions"}],"predecessor-version":[{"id":69710,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69693\/revisions\/69710"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media\/69694"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=69693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=69693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=69693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}