Merck se pr\u00e9pare \u00e0 une baisse significative des ventes de son m\u00e9dicament phare en oncologie, Keytruda, \u00e0 partir de 2028. Deux raisons expliquent cela : l’expiration d’un brevet cl\u00e9 aux \u00c9tats-Unis \u00e0 la fin de cette ann\u00e9e-l\u00e0, et l’anticipation que le gouvernement am\u00e9ricain choisisse le m\u00e9dicament pour le processus de fixation de prix pr\u00e9vu par l’Inflation Reduction Act en 2026. Les prix n\u00e9goci\u00e9s entreront en vigueur en janvier 2028, selon un r\u00e9cent rapport d\u00e9pos\u00e9 par Merck.<\/p>\n
La soci\u00e9t\u00e9 craint l’ann\u00e9e 2028 depuis longtemps \u00e0 cause de l’expiration du brevet, mais elle a cherch\u00e9 \u00e0 r\u00e9aliser des accords pour att\u00e9nuer la chute des ventes de Keytruda et stimuler sa croissance future. Avec plus de 40 indications aux \u00c9tats-Unis et 30 en Europe, Keytruda est le principal moteur de ventes de Merck, g\u00e9n\u00e9rant 29 milliards de dollars en 2024.<\/p>\n
Bien qu’aucun biosimilaire n’ait encore \u00e9t\u00e9 approuv\u00e9, plusieurs entreprises comme Celltrion, Samsung Bioepis et Amgen d\u00e9veloppent des copies. En Europe, Keytruda b\u00e9n\u00e9ficiera d’une exclusivit\u00e9 de march\u00e9 jusqu’en 2031.<\/p>\n
L’IRA pose un d\u00e9fi diff\u00e9rent. Merck a d\u00e9j\u00e0 vu deux de ses m\u00e9dicaments, dont Januvia, soumis \u00e0 des r\u00e9ductions de prix importantes. Merck a poursuivi le gouvernement am\u00e9ricain en 2023, all\u00e9guant des violations constitutionnelles li\u00e9es \u00e0 ces n\u00e9gociations de prix. Le minist\u00e8re de la Sant\u00e9 a r\u00e9pondu que Merck n’avait pas de motifs suffisants pour saisir la justice.<\/p>\n
Merck continue de s’opposer \u00e0 ces mesures, car elles pourraient nuire \u00e0 l’innovation dans l’industrie pharmaceutique. Le PDG de Merck, Robert Davis, a averti que des d\u00e9couvertes comme Keytruda seraient impossibles sous l’IRA. <\/p>\n
L’IRA, adopt\u00e9e en 2022 sous l’administration de Joe Biden, pourrait \u00eatre modifi\u00e9e sous une nouvelle administration Trump, esp\u00e8rent certains dans l’industrie. R\u00e9cemment, les Centres pour Medicare & Medicaid Services ont promis d’am\u00e9liorer le programme de n\u00e9gociation.<\/p>\n
Cependant, le gouvernement soutient les arguments juridiques de l’administration Biden dans un litige en cours impliquant Novartis. Cette situation s’est produite avant une r\u00e9union entre le Pr\u00e9sident Trump et les dirigeants de PhRMA pour discuter de possibles ajustements \u00e0 certaines dispositions de l’IRA.<\/p>\n","protected":false},"excerpt":{"rendered":"
Merck se pr\u00e9pare \u00e0 un ralentissement de la croissance des ventes de son m\u00e9dicament vedette en oncologie, Keytruda, \u00e0 partir de 2028, et cela pour plusieurs raisons.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-69596","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=69596"}],"version-history":[{"count":0,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69596\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=69596"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=69596"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=69596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}