Parmi les 49 patients adultes recrut\u00e9s pour l’essai, 41,2 % de ceux trait\u00e9s avec Ecopipam ont connu une forme de rechute. Emalex Biosciences cherche \u00e0 obtenir l’approbation de son traitement pour le syndrome de Tourette apr\u00e8s avoir atteint ses objectifs principaux et secondaires dans une \u00e9tude de phase III.<\/p>\n
Le m\u00e9dicament de l’entreprise am\u00e9ricaine, Ecopipam, qui agit comme un antagoniste du r\u00e9cepteur de la dopamine-1, a montr\u00e9 des r\u00e9sultats positifs chez les patients adultes et p\u00e9diatriques atteints de ce syndrome, caract\u00e9ris\u00e9 notamment par des tics involontaires. Chez les patients p\u00e9diatriques, le taux de rechute \u00e9tait de 41,9 % contre 68,1 % pour le groupe placebo. Suite \u00e0 ces r\u00e9sultats, Emalex pr\u00e9voit de rencontrer la FDA et d’autres autorit\u00e9s de sant\u00e9 pour discuter d’une demande d’approbation en 2025.<\/p>\n
L’\u00e9tude DIAMOND a impliqu\u00e9 167 sujets p\u00e9diatriques et 49 adultes atteints du syndrome de Tourette. Les r\u00e9sultats ont montr\u00e9 une r\u00e9duction significative des tics vocaux et moteurs chez les patients p\u00e9diatriques trait\u00e9s avec Ecopipam sur une p\u00e9riode de 12 semaines. Ensuite, les patients ont \u00e9t\u00e9 r\u00e9partis de mani\u00e8re al\u00e9atoire pour continuer avec le m\u00e9dicament ou un placebo pendant encore 12 semaines.<\/p>\n
Frederick Munschauer, directeur m\u00e9dical d’Emalex, a d\u00e9clar\u00e9 : “Ces r\u00e9sultats renforcent notre confiance en Ecopipam comme un traitement potentiel novateur pour le syndrome de Tourette.”<\/p>\n
En 2024, le march\u00e9 mondial des th\u00e9rapies pour le syndrome de Tourette \u00e9tait estim\u00e9 \u00e0 environ 248 millions de dollars, mais il pourrait chuter \u00e0 84 millions d’ici 2030. Parmi les m\u00e9dicaments disponibles, l’Abilify (aripiprazole) d’Otsuka Holdings est le plus couramment utilis\u00e9.<\/p>\n
Selon le CDC, aux \u00c9tats-Unis, un enfant sur 333 \u00e2g\u00e9 de 3 \u00e0 17 ans est diagnostiqu\u00e9 avec le syndrome de Tourette, les gar\u00e7ons \u00e9tant trois fois plus susceptibles d’\u00eatre touch\u00e9s que les filles.<\/p>\n
Eric Messner, PDG d’Emalex, a ajout\u00e9 : “Nous esp\u00e9rons qu’Ecopipam pourra offrir un soulagement symptomatique aux patients atteints du syndrome de Tourette.”<\/p>\n
Par ailleurs, la soci\u00e9t\u00e9 pharmaceutique isra\u00e9lienne SciSparc a re\u00e7u l’approbation de la FDA pour un essai clinique de phase IIb de son m\u00e9dicament SCI-110 chez les adultes atteints de ce syndrome.<\/p>\n
Inscrivez-vous \u00e0 notre newsletter quotidienne pour des informations de pointe sur l’industrie.<\/p>\n","protected":false},"excerpt":{"rendered":"
L’essai de Phase III DIAMOND a atteint ses objectifs principaux et secondaires en r\u00e9duisant les tics chez les enfants et les adultes. Si possible, incluez le nom de certains m\u00e9dicaments.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[684],"tags":[],"class_list":["post-69586","post","type-post","status-publish","format-standard","hentry","category-nouvelles-pharmaceutiques"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69586","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=69586"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69586\/revisions"}],"predecessor-version":[{"id":69632,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69586\/revisions\/69632"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=69586"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=69586"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=69586"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}