L’acquisition inclura l’ALIA-1758 d’Aliada, en d\u00e9veloppement pour la maladie d’Alzheimer. AbbVie a conclu un accord d\u00e9finitif pour acqu\u00e9rir toutes les actions d’Aliada Therapeutics pour 1,4 milliard de dollars en liquide. L’accord comprendra le produit en d\u00e9veloppement principal d’Aliada, l’ALIA-1758, visant \u00e0 traiter la maladie d’Alzheimer.<\/p>\n
Aliada est \u00e0 la pointe des th\u00e9rapies utilisant une technologie permettant de franchir la barri\u00e8re h\u00e9mato-enc\u00e9phalique (BHE), ciblant les r\u00e9cepteurs de la transferrine et CD98, pr\u00e9sents en abondance dans les cellules endoth\u00e9liales c\u00e9r\u00e9brales. Cette technologie est essentielle \u00e0 sa plateforme de livraison modulable (MODEL), con\u00e7ue pour une administration pr\u00e9cise de m\u00e9dicaments au syst\u00e8me nerveux central.<\/p>\n
L’ALIA-1758 utilise cette technologie pour transporter un anticorps anti-pyroglutamate b\u00eata amylo\u00efde \u00e0 travers la BHE, dans le but de d\u00e9grader les plaques amylo\u00efdes b\u00eata associ\u00e9es \u00e0 la maladie d’Alzheimer. La plateforme MODEL, initialement d\u00e9velopp\u00e9e par des scientifiques de Johnson & Johnson, est con\u00e7ue pour acheminer des \u00e9l\u00e9ments biologiques vers le cerveau.<\/p>\n
L’acquisition par AbbVie devrait renforcer les capacit\u00e9s de recherche et d\u00e9veloppement (R&D) de l’entreprise, acc\u00e9l\u00e9rant le d\u00e9veloppement de nouvelles th\u00e9rapies pour les troubles neurologiques. Roopal Thakkar, vice-pr\u00e9sident ex\u00e9cutif de la R&D chez AbbVie, a d\u00e9clar\u00e9 : \u00ab La neuroscience est l’un de nos domaines de croissance cl\u00e9s et nous nous engageons \u00e0 innover dans ce domaine pour r\u00e9pondre aux besoins non satisfaits des patients souffrant de maladies neurologiques graves comme la maladie d’Alzheimer. \u00bb<\/p>\n
L’ALIA-1758 est actuellement en phase I d’essai clinique pour \u00e9valuer sa tol\u00e9rabilit\u00e9 et sa s\u00e9curit\u00e9 chez des participants en bonne sant\u00e9. La transaction, soumise aux approbations r\u00e9glementaires et aux conditions de cl\u00f4ture habituelles, sera finalis\u00e9e au quatri\u00e8me trimestre 2024. AbbVie a \u00e9t\u00e9 conseill\u00e9e l\u00e9galement par Covington & Burling, tandis que Centerview Partners a fourni des conseils financiers et Fenwick & West des services juridiques \u00e0 Aliada.<\/p>\n","protected":false},"excerpt":{"rendered":"
L’acquisition inclura l’ALIA-1758 d’Aliada, en d\u00e9veloppement pour la maladie d’Alzheimer. AbbVie a conclu un accord d\u00e9finitif pour acqu\u00e9rir toutes les actions d’Aliada Therapeutics pour 1,4 milliard de dollars en liquide. L’accord comprendra le produit en d\u00e9veloppement principal d’Aliada, l’ALIA-1758, visant \u00e0 traiter la maladie d’Alzheimer. Aliada est \u00e0 la pointe des th\u00e9rapies utilisant une technologie […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[684],"tags":[],"class_list":["post-69568","post","type-post","status-publish","format-standard","hentry","category-nouvelles-pharmaceutiques"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69568","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=69568"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69568\/revisions"}],"predecessor-version":[{"id":69575,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69568\/revisions\/69575"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=69568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=69568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=69568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}