MVA-BN est commercialis\u00e9 sous le nom de Jynneos aux \u00c9tats-Unis et Imvanex en Europe. Cr\u00e9dit image : Sonia Bonet \/ Shutterstock.<\/p>\n
Bavarian Nordic cherche \u00e0 \u00e9largir l’autorisation de son vaccin contre la variole du singe\/variole, MVA-BN, pour inclure les enfants de 2 \u00e0 11 ans et a lanc\u00e9 un essai de Phase II pour soutenir cette approbation. Cette \u00e9tude (NCT06549530) compare la s\u00e9curit\u00e9 et l’efficacit\u00e9 du vaccin chez les enfants de ce groupe d’\u00e2ge par rapport aux adultes. L’essai est partiellement financ\u00e9 par la Coalition pour les innovations en mati\u00e8re de pr\u00e9paration aux \u00e9pid\u00e9mies (CEPI).<\/p>\n
La soci\u00e9t\u00e9 danoise souhaite recruter des participants en R\u00e9publique d\u00e9mocratique du Congo et potentiellement en Ouganda. L’Organisation mondiale de la sant\u00e9 (OMS) a d\u00e9clar\u00e9 une urgence de sant\u00e9 publique mondiale concernant la variole du singe en ao\u00fbt, apr\u00e8s la propagation d’un nouveau type de virus depuis la R\u00e9publique d\u00e9mocratique du Congo vers les pays voisins.<\/p>\n
MVA-BN est un vaccin contre la variole du singe qui ne se r\u00e9plique pas. Il est commercialis\u00e9 sous le nom de Jynneos aux \u00c9tats-Unis et Imvanex en Europe. En septembre, l’Agence europ\u00e9enne des m\u00e9dicaments (EMA) a \u00e9tendu la port\u00e9e du vaccin aux adolescents de plus de 12 ans. Le m\u00eame mois, l’Alliance mondiale pour les vaccins et la vaccination (GAVI) a conclu un accord d’achat avec Bavarian Nordic pour s\u00e9curiser 500 000 doses pour les pays africains.<\/p>\n
Bien que cet essai de Phase II soit la premi\u00e8re \u00e9valuation du MVA-BN comme vaccin contre la variole du singe\/variole pour les jeunes enfants, une version recombinante, Mvabea, a \u00e9t\u00e9 approuv\u00e9e par l’EMA en 2020 pour pr\u00e9venir la maladie caus\u00e9e par le virus Ebola chez les personnes d’un an et plus.<\/p>\n
Selon Dr Nicole Lurie de la CEPI, les r\u00e9sultats de cette \u00e9tude seront essentiels pour d\u00e9velopper des strat\u00e9gies de vaccination contre la variole du singe, prot\u00e9geant les enfants et mettant fin \u00e0 l’\u00e9pid\u00e9mie, tout en fournissant des recommandations locales pour contrer les futures \u00e9pid\u00e9mies.<\/p>\n
Le vaccin contre la variole du singe\/variole a \u00e9t\u00e9 une source majeure de revenus pour Bavarian Nordic, g\u00e9n\u00e9rant 5 milliards DKK (724 millions USD) l’ann\u00e9e derni\u00e8re. Un autre vaccin en d\u00e9veloppement est celui \u00e0 base d’ARNm de Moderna, actuellement test\u00e9 dans une \u00e9tude de Phase I\/II (NCT05995275).<\/p>\n
Inscrivez-vous \u00e0 notre newsletter quotidienne pour obtenir un avantage concurrentiel avec nos pr\u00e9cieuses analyses sectorielles.<\/p>\n","protected":false},"excerpt":{"rendered":"
MVA-BN est commercialis\u00e9 sous le nom de Jynneos aux \u00c9tats-Unis et Imvanex en Europe. Cr\u00e9dit image : Sonia Bonet \/ Shutterstock. Bavarian Nordic cherche \u00e0 \u00e9largir l’autorisation de son vaccin contre la variole du singe\/variole, MVA-BN, pour inclure les enfants de 2 \u00e0 11 ans et a lanc\u00e9 un essai de Phase II pour soutenir […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[684],"tags":[],"class_list":["post-69565","post","type-post","status-publish","format-standard","hentry","category-nouvelles-pharmaceutiques"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=69565"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69565\/revisions"}],"predecessor-version":[{"id":69578,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69565\/revisions\/69578"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=69565"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=69565"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=69565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}