SURMOUNT-1<\/a>, le m\u00e9dicament a encore consolid\u00e9 son impressionnant profil de perte de poids : les adultes prenant la dose de 15 mg du double agoniste GIP\/GLP-1 ont perdu en moyenne 22,9% de leur poids corporel, contre une modeste r\u00e9duction de 2,1% pour ceux du bras de contr\u00f4le de l’essai.
\nEn moyenne, les patients sous les doses de 5 mg et 10 mg de tirz\u00e9patide ont perdu respectivement 15,4% et 19,9% de leur poids corporel.<\/p>\nJeff Emmick, M.D., Ph.D., SVP du d\u00e9veloppement de produits de Lilly, a d\u00e9clar\u00e9 dans un communiqu\u00e9 que les r\u00e9sultats soutiennent les avantages potentiels du traitement \u00e0 long terme par tirz\u00e9patide pour les personnes vivant avec l’ob\u00e9sit\u00e9 et le pr\u00e9diab\u00e8te.
\nL’\u00e9tude a test\u00e9 le m\u00e9dicament sur 1 032 adultes qui avaient un pr\u00e9diab\u00e8te au moment de la randomisation et une ob\u00e9sit\u00e9 ou un surpoids pendant une dur\u00e9e de 176 semaines, suivie d’une p\u00e9riode de 17 semaines sans traitement.
\nLilly a not\u00e9 que pendant la p\u00e9riode de 17 semaines sans traitement, les patients qui ont arr\u00eat\u00e9 de prendre le m\u00e9dicament ont commenc\u00e9 \u00e0 reprendre du poids et “ont eu une certaine augmentation de la progression vers le diab\u00e8te de type 2.”<\/p>\n
La s\u00e9curit\u00e9 \u00e9tait conforme au profil \u00e9tabli du tirz\u00e9patide, les patients exp\u00e9rimentant le plus souvent des effets secondaires tels que diarrh\u00e9e, naus\u00e9es, constipation et vomissements.
\nCes donn\u00e9es sur le pr\u00e9diab\u00e8te font suite \u00e0 une s\u00e9rie de succ\u00e8s pour le m\u00e9dicament, qui a d\u00e9j\u00e0 fait ses preuves dans des conditions telles que le diab\u00e8te, l’ob\u00e9sit\u00e9, l’insuffisance cardiaque, l’apn\u00e9e du sommeil et la maladie du foie gras.<\/p>\n
Malgr\u00e9 des contraintes p\u00e9riodiques d’approvisionnement, Mounjaro et Zepbound ont connu un grand succ\u00e8s pour Lilly, qui a r\u00e9cemment augment\u00e9 ses pr\u00e9visions annuelles de 3 milliards de dollars. Au deuxi\u00e8me trimestre, Mounjaro a g\u00e9n\u00e9r\u00e9 3,09 milliards de dollars, tandis que Zepbound a rapport\u00e9 1,24 milliard de dollars.<\/p>\n
Les probl\u00e8mes d’approvisionnement semblent avoir \u00e9t\u00e9 r\u00e9solus pour l’instant. Au d\u00e9but de ce mois, toutes les doses de Mounjaro et Zepbound \u00e9taient r\u00e9pertori\u00e9es comme disponibles dans la base de donn\u00e9es en ligne de la FDA sur les p\u00e9nuries de m\u00e9dicaments.<\/p>\n","protected":false},"excerpt":{"rendered":"
Le tirz\u00e9patide d’Eli Lilly, d\u00e9j\u00e0 extr\u00eamement populaire pour le diab\u00e8te de type 2 et l’ob\u00e9sit\u00e9, peut maintenant aider \u00e0 pr\u00e9venir l’une des maladies qu’il est cens\u00e9 traiter, comme le montrent de nouvelles donn\u00e9es. Chez les adultes atteints de pr\u00e9diab\u00e8te et d’ob\u00e9sit\u00e9 ou de surpoids, des injections hebdomadaires de tirz\u00e9patide \u00e0 diff\u00e9rentes doses (5 mg, 10 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[684],"tags":[],"class_list":["post-69536","post","type-post","status-publish","format-standard","hentry","category-nouvelles-pharmaceutiques"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69536","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=69536"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69536\/revisions"}],"predecessor-version":[{"id":69537,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69536\/revisions\/69537"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=69536"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=69536"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=69536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}