{"id":69435,"date":"2024-01-13T17:44:44","date_gmt":"2024-01-13T17:44:44","guid":{"rendered":"https:\/\/www.pharmacie-vezere.com\/promotions\/?p=69435"},"modified":"2024-01-13T17:44:47","modified_gmt":"2024-01-13T17:44:47","slug":"les-chercheurs-decouvrent-la-cle-pour-ralentir-le-vieillissement-du-cerveau-et-prolonger-la-duree-de-vie-grace-a-lalimentation","status":"publish","type":"post","link":"https:\/\/www.pharmacie-vezere.com\/promotions\/les-chercheurs-decouvrent-la-cle-pour-ralentir-le-vieillissement-du-cerveau-et-prolonger-la-duree-de-vie-grace-a-lalimentation\/","title":{"rendered":"Les chercheurs d\u00e9couvrent la cl\u00e9 pour ralentir le vieillissement du cerveau et prolonger la dur\u00e9e de vie gr\u00e2ce \u00e0 l&#8217;alimentation"},"content":{"rendered":"\n<p><strong><em>La restriction calorique, connue depuis longtemps pour ses bienfaits sur la sant\u00e9 et la long\u00e9vit\u00e9, cache des secrets, en particulier sur la mani\u00e8re dont elle prot\u00e8ge le cerveau. Des d\u00e9couvertes r\u00e9centes \u00e0 l&#8217;Institut Buck ont mis en lumi\u00e8re un g\u00e8ne, OXR1, essentiel \u00e0 la fois pour l&#8217;extension de la dur\u00e9e de vie li\u00e9e \u00e0 la restriction di\u00e9t\u00e9tique et pour un vieillissement sain du cerveau.<\/em><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"259\" height=\"194\" src=\"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-content\/uploads\/2024\/01\/diet-and-longlivety.jpg\" alt=\"\" class=\"wp-image-69437\" style=\"width:466px;height:auto\" srcset=\"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-content\/uploads\/2024\/01\/diet-and-longlivety.jpg 259w, https:\/\/www.pharmacie-vezere.com\/promotions\/wp-content\/uploads\/2024\/01\/diet-and-longlivety-200x150.jpg 200w\" sizes=\"auto, (max-width: 259px) 100vw, 259px\" \/><\/figure>\n\n\n\n<p>Kenneth Wilson, Ph.D., postdoctorant \u00e0 Buck et premier auteur de l&#8217;\u00e9tude, souligne l&#8217;impact inattendu des choix alimentaires sur la sant\u00e9 c\u00e9r\u00e9brale. &#8220;Quand les gens limitent leur apport alimentaire, ils pensent peut-\u00eatre aux effets sur la digestion ou la graisse, mais pas au cerveau&#8221;, dit-il. L&#8217;\u00e9tude, publi\u00e9e dans Nature Communications le 11 janvier 2024, r\u00e9v\u00e8le que OXR1 est vital dans le cerveau, sugg\u00e9rant des liens plus profonds entre l&#8217;alimentation et le bien-\u00eatre neuronal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Neuroprotection et Vieillissement : Le R\u00f4le de l&#8217;Alimentation<\/h2>\n\n\n\n<p>La recherche de l&#8217;\u00e9quipe de Buck, utilisant des mouches \u00e0 fruit et des cellules humaines, d\u00e9montre comment la restriction alimentaire peut retarder le vieillissement et ralentir la progression des maladies neurod\u00e9g\u00e9n\u00e9ratives. Ce travail identifie des cibles th\u00e9rapeutiques potentielles pour lutter contre le vieillissement et les troubles neurologiques li\u00e9s.<\/p>\n\n\n\n<p>Le professeur Pankaj Kapahi, Ph.D., co-auteur principal de Buck, met en \u00e9vidence une r\u00e9ponse sp\u00e9cifique aux neurones sous-tendant les effets neuroprotecteurs de la restriction alimentaire. &#8220;Limiter les nutriments par le je\u00fbne intermittent ou la restriction calorique peut augmenter les niveaux de OXR1, assurant la protection&#8221;, explique-t-il. Le professeur Lisa Ellerby, Ph.D., ajoute que OXR1 sert de facteur crucial dans la r\u00e9silience c\u00e9r\u00e9brale contre le vieillissement et les maladies neurologiques.<\/p>\n\n\n\n<p>L&#8217;\u00e9tude a commenc\u00e9 par examiner environ 200 souches de mouches \u00e0 fruit sous des r\u00e9gimes normaux et restreints. Cela a conduit \u00e0 l&#8217;identification de cinq g\u00e8nes, dont &#8220;mustard&#8221; (mtd) chez les mouches et &#8220;Oxidation Resistance 1&#8221; (OXR1) chez l&#8217;homme et la souris, influen\u00e7ant la long\u00e9vit\u00e9 sous restriction di\u00e9t\u00e9tique. La perte de OXR1 chez l&#8217;homme entra\u00eene de graves probl\u00e8mes neurologiques et une mort pr\u00e9coce, tandis que son abondance chez la souris am\u00e9liore la survie dans les mod\u00e8les de scl\u00e9rose lat\u00e9rale amyotrophique (SLA).<\/p>\n\n\n\n<p>Le lien entre le vieillissement du cerveau, la neurod\u00e9g\u00e9n\u00e9rescence et la dur\u00e9e de vie est encore explor\u00e9 \u00e0 travers le r\u00f4le de OXR1 dans le complexe r\u00e9trom\u00e8re, essentiel pour le recyclage des prot\u00e9ines et lipides cellulaires. Wilson note, &#8220;Le r\u00e9trom\u00e8re est significatif dans les neurones, car il d\u00e9cide du sort des prot\u00e9ines entrant dans la cellule.&#8221; Les dysfonctionnements dans ce complexe sont li\u00e9s \u00e0 la maladie d&#8217;Alzheimer et \u00e0 la maladie de Parkinson, maladies att\u00e9nu\u00e9es par la restriction alimentaire.<\/p>\n\n\n\n<p>Les r\u00e9sultats de l&#8217;\u00e9quipe r\u00e9v\u00e8lent comment la restriction alimentaire ralentit le vieillissement c\u00e9r\u00e9bral via le r\u00f4le de mtd\/OXR1 dans le maintien de la fonction r\u00e9trom\u00e8re. &#8220;Manger moins am\u00e9liore le tri des prot\u00e9ines dans les cellules en augmentant l&#8217;expression de OXR1&#8221;, conclut Wilson.<\/p>\n\n\n\n<p>L&#8217;\u00e9tude ouvre de nouvelles voies, les chercheurs visant d\u00e9sormais \u00e0 trouver des compos\u00e9s qui augmentent les niveaux de OXR1, potentiellement retardant le vieillissement du cerveau et prolongeant la dur\u00e9e de vie.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La restriction calorique, connue depuis longtemps pour ses bienfaits sur la sant\u00e9 et la long\u00e9vit\u00e9, cache des secrets, en particulier sur la mani\u00e8re dont elle prot\u00e8ge le cerveau. Des d\u00e9couvertes r\u00e9centes \u00e0 l&#8217;Institut Buck ont mis en lumi\u00e8re un g\u00e8ne, OXR1, essentiel \u00e0 la fois pour l&#8217;extension de la dur\u00e9e de vie li\u00e9e \u00e0 la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":69438,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[684],"tags":[],"class_list":["post-69435","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nouvelles-pharmaceutiques"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69435","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=69435"}],"version-history":[{"count":2,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69435\/revisions"}],"predecessor-version":[{"id":69439,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69435\/revisions\/69439"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media\/69438"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=69435"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=69435"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=69435"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}