{"id":69251,"date":"2023-12-02T17:51:56","date_gmt":"2023-12-02T17:51:56","guid":{"rendered":"https:\/\/www.pharmacie-vezere.com\/promotions\/?p=69251"},"modified":"2023-12-02T17:51:59","modified_gmt":"2023-12-02T17:51:59","slug":"un-vaccin-nasal-prometteur-pour-prevenir-la-propagation-du-covid-19-et-au-dela","status":"publish","type":"post","link":"https:\/\/www.pharmacie-vezere.com\/promotions\/un-vaccin-nasal-prometteur-pour-prevenir-la-propagation-du-covid-19-et-au-dela\/","title":{"rendered":"Un Vaccin Nasal Prometteur pour Pr\u00e9venir la Propagation du COVID-19 et Au-del\u00e0"},"content":{"rendered":"\n

Une \u00e9quipe de chercheurs de l’Universit\u00e9 du Maryland a mis au point un vaccin r\u00e9volutionnaire sous forme de spray nasal qui a d\u00e9montr\u00e9 son efficacit\u00e9 pour r\u00e9duire la propagation du COVID-19. La technologie, d\u00e9crite dans un article de recherche publi\u00e9 dans Nature Communications le 6 novembre 2023, pourrait potentiellement \u00eatre adapt\u00e9e pour conf\u00e9rer une immunit\u00e9 contre d’autres virus respiratoires tels que la grippe et le virus respiratoire syncytial (VRS).<\/strong><\/p>\n\n\n\n

\"\"
Close up Hands of Doctor or nurse holding Intranasal vaccine spray bottle for coronavirus or covid-19 pandemic.<\/figcaption><\/figure>\n\n\n\n

Le vaccin nasal repr\u00e9sente une avanc\u00e9e significative par rapport aux injections intramusculaires traditionnelles. En d\u00e9livrant directement la prot\u00e9ine de pointe du SARS-CoV-2 dans les cellules des voies respiratoires de souris et de hamsters, le vaccin d\u00e9clenche une r\u00e9ponse immunitaire puissante. Cette r\u00e9ponse r\u00e9duit non seulement de mani\u00e8re significative les taux d’infection, mais entrave \u00e9galement la r\u00e9plication des particules virales dans les voies respiratoires avant qu’elles n’entrent dans la circulation sanguine.<\/p>\n\n\n\n

Le professeur Xiaoping Zhu, auteur principal de l’\u00e9tude et expert en m\u00e9decine v\u00e9t\u00e9rinaire \u00e0 l’UMD, souligne l’importance d’un vaccin facile \u00e0 administrer et capable de pr\u00e9venir la transmission. “Ce vaccin nasal pr\u00e9vient la transmission du virus et peut \u00eatre facilement adapt\u00e9 aux nouveaux variants”, d\u00e9clare Zhu.<\/p>\n\n\n\n

Contrairement aux vaccins intramusculaires qui cr\u00e9ent principalement une immunit\u00e9 dans la circulation sanguine, le nouveau vaccin nasal induit une immunit\u00e9 dans les cellules tapissant le nez, la bouche et la gorge. Ce faisant, il emp\u00eache le virus de progresser davantage dans le corps.<\/p>\n\n\n\n

Les chercheurs ont exploit\u00e9 le m\u00e9canisme naturel de transport du corps en utilisant une prot\u00e9ine appel\u00e9e r\u00e9cepteur Fc n\u00e9onatal (FcRn) pour transporter les anticorps \u00e0 travers les cellules \u00e9pith\u00e9liales. En attachant la prot\u00e9ine de pointe du SARS-CoV-2 \u00e0 FcRn et en la pulv\u00e9risant par voie nasale, l’\u00e9quipe a observ\u00e9 une r\u00e9ponse immunitaire plus puissante dans les voies respiratoires et les poumons par rapport aux injections traditionnelles.<\/p>\n\n\n\n

Les tests du vaccin contre divers variants du COVID-19, y compris Delta et Omicron, ont r\u00e9v\u00e9l\u00e9 des r\u00e9sultats prometteurs. Alors que les souris non vaccin\u00e9es expos\u00e9es au variant Delta ont connu des taux de mortalit\u00e9 \u00e9lev\u00e9s, la plupart des souris vaccin\u00e9es ont surv\u00e9cu. De plus, les souris expos\u00e9es aux principaux variants d’Omicron ont montr\u00e9 une r\u00e9duction significative de l’inflammation et de la charge virale par rapport \u00e0 leurs homologues non vaccin\u00e9s.<\/p>\n\n\n\n

De plus, le vaccin nasal a d\u00e9montr\u00e9 une r\u00e9duction significative de la transmission a\u00e9rienne, un facteur crucial compte tenu de la capacit\u00e9 potentielle des particules virales \u00e0 persister dans l’air pendant des p\u00e9riodes prolong\u00e9es.<\/p>\n\n\n\n

\u00c0 mesure que les cas de COVID-19 et les hospitalisations augmentent en raison de nouveaux variants, le vaccin nasal offre une solution prometteuse. En accord avec l’initiative Project NextGen du gouvernement am\u00e9ricain, visant \u00e0 d\u00e9velopper un vaccin nasal efficace, l’\u00e9quipe du professeur Zhu estime que sa cr\u00e9ation r\u00e9pond aux crit\u00e8res de contr\u00f4le de la propagation des variants.<\/p>\n\n\n\n

L’effort collaboratif, impliquant des chercheurs de l’UMD, du USDA ARS et de Virginia Tech, a re\u00e7u le soutien d’organisations telles que les National Institutes of Health NIAID, l’University of Maryland Agriculture Experiment Station et le programme de recherche intramuros de l’USDA ARS.<\/p>\n\n\n\n

En conclusion, le vaccin nasal sous forme de spray repr\u00e9sente une avanc\u00e9e notable dans la lutte contre le COVID-19, offrant l’espoir d’am\u00e9liorer les taux de vaccination et de r\u00e9duire la transmission de la maladie.<\/p>\n","protected":false},"excerpt":{"rendered":"

Une \u00e9quipe de chercheurs de l’Universit\u00e9 du Maryland a mis au point un vaccin r\u00e9volutionnaire sous forme de spray nasal qui a d\u00e9montr\u00e9 son efficacit\u00e9 pour r\u00e9duire la propagation du COVID-19. La technologie, d\u00e9crite dans un article de recherche publi\u00e9 dans Nature Communications le 6 novembre 2023, pourrait potentiellement \u00eatre adapt\u00e9e pour conf\u00e9rer une immunit\u00e9 […]<\/p>\n","protected":false},"author":1,"featured_media":69253,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[684],"tags":[],"class_list":["post-69251","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nouvelles-pharmaceutiques"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=69251"}],"version-history":[{"count":1,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69251\/revisions"}],"predecessor-version":[{"id":69254,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/69251\/revisions\/69254"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media\/69253"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=69251"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=69251"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=69251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}