{"id":68858,"date":"2023-05-05T15:35:20","date_gmt":"2023-05-05T15:35:20","guid":{"rendered":"https:\/\/www.pharmacie-vezere.com\/promotions\/?p=68858"},"modified":"2023-05-05T16:18:28","modified_gmt":"2023-05-05T16:18:28","slug":"la-nouvelle-technique-dedition-de-genes-en-double-combinee-a-laser-art-augmente-la-possibilite-deliminer-linfection-par-le-vih","status":"publish","type":"post","link":"https:\/\/www.pharmacie-vezere.com\/promotions\/la-nouvelle-technique-dedition-de-genes-en-double-combinee-a-laser-art-augmente-la-possibilite-deliminer-linfection-par-le-vih\/","title":{"rendered":"La nouvelle technique d&#8217;\u00e9dition de g\u00e8nes en double combin\u00e9e \u00e0 LASER ART augmente la possibilit\u00e9 d&#8217;\u00e9liminer l&#8217;infection par le VIH"},"content":{"rendered":"\n<p>Des chercheurs ont publi\u00e9 une \u00e9tude dans PNAS qui a r\u00e9v\u00e9l\u00e9 qu&#8217;une perc\u00e9e prometteuse dans l&#8217;\u00e9limination du virus de l&#8217;immunod\u00e9ficience humaine de type 1 (VIH-1) chez des souris humanis\u00e9es et infect\u00e9es a \u00e9t\u00e9 r\u00e9alis\u00e9e en combinant deux th\u00e9rapies de modification g\u00e9n\u00e9tique CRISPR avec une th\u00e9rapie antir\u00e9trovirale (ART). Cette approche r\u00e9volutionnaire de traitement pourrait transformer la prise en charge du VIH-1 chez les humains.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"540\" src=\"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-content\/uploads\/2023\/05\/dual-gene-editing-strategy-to-combat-hiv-372804-960x540-1.jpg\" alt=\"\" class=\"wp-image-68864\" srcset=\"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-content\/uploads\/2023\/05\/dual-gene-editing-strategy-to-combat-hiv-372804-960x540-1.jpg 960w, https:\/\/www.pharmacie-vezere.com\/promotions\/wp-content\/uploads\/2023\/05\/dual-gene-editing-strategy-to-combat-hiv-372804-960x540-1-300x169.jpg 300w, https:\/\/www.pharmacie-vezere.com\/promotions\/wp-content\/uploads\/2023\/05\/dual-gene-editing-strategy-to-combat-hiv-372804-960x540-1-768x432.jpg 768w, https:\/\/www.pharmacie-vezere.com\/promotions\/wp-content\/uploads\/2023\/05\/dual-gene-editing-strategy-to-combat-hiv-372804-960x540-1-200x113.jpg 200w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>L&#8217;excision de l&#8217;ADN de HIV-1 et l&#8217;inactivation de CCR5 ont \u00e9t\u00e9 combin\u00e9es en utilisant des technologies d&#8217;\u00e9dition de g\u00e8nes construites sur des observations de gu\u00e9risons signal\u00e9es chez des patients humains [atteints du VIH]. Dans les rares cas de gu\u00e9risons du VIH chez l&#8217;homme, les patients ont subi une greffe de moelle osseuse pour une leuc\u00e9mie et les cellules donneuses utilis\u00e9es portaient des mutations inactivantes de CCR5,<\/p>\n<cite>a d\u00e9clar\u00e9 l&#8217;auteur de l&#8217;\u00e9tude Kamel Khalili, PhD, professeur Laura H. Carnell et directeur du d\u00e9partement de microbiologie, d&#8217;immunologie et d&#8217;inflammation et directeur de la Lewis Katz School of Medicine, dans un communiqu\u00e9 de presse.<\/cite><\/blockquote>\n\n\n\n<p>La technologie double CRISPR d\u00e9velopp\u00e9e dans l&#8217;\u00e9tude cible sp\u00e9cifiquement deux zones : le cor\u00e9cepteur de type 5 de la chimiokine C-C (CCR5) du virus du VIH-1, qui permet au virus d&#8217;entrer dans les cellules, et la r\u00e9gion LTR-Gag des cellules infect\u00e9es, o\u00f9 l&#8217;ADN viral dormant est pr\u00e9sent. En ciblant ces deux zones critiques, les chercheurs ont pu \u00e9liminer efficacement le virus du VIH-1 chez des souris humanis\u00e9es et infect\u00e9es, offrant ainsi de l&#8217;espoir pour une \u00e9ventuelle gu\u00e9rison \u00e0 l&#8217;avenir.<\/p>\n\n\n\n<p>La th\u00e9rapie antir\u00e9trovirale (TAR) est actuellement le traitement standard pour le VIH-1, mais elle ne supprime que le virus et ne l&#8217;\u00e9limine pas compl\u00e8tement du corps. Cela signifie que les personnes recevant la TAR sont toujours expos\u00e9es au risque de d\u00e9velopper le syndrome d&#8217;immunod\u00e9ficience acquise (SIDA) et d&#8217;autres complications associ\u00e9es au VIH-1. Cependant, l&#8217;\u00e9tude a montr\u00e9 que l&#8217;approche double technologie CRISPR a \u00e9t\u00e9 capable d&#8217;\u00e9liminer compl\u00e8tement le virus du VIH-1 chez certaines souris trait\u00e9es, fournissant ainsi des preuves de l&#8217;efficacit\u00e9 potentielle de cette approche de traitement innovante chez l&#8217;homme.<\/p>\n\n\n\n<p>Dans l&#8217;ensemble, cette \u00e9tude constitue une avanc\u00e9e importante dans le d\u00e9veloppement d&#8217;un rem\u00e8de contre le VIH-1. En ciblant le virus \u00e0 sa source et en l&#8217;\u00e9liminant compl\u00e8tement, cette approche de traitement r\u00e9volutionnaire peut offrir un nouvel espoir aux personnes vivant avec le VIH-1, et finalement conduire \u00e0 l&#8217;\u00e9radication de ce virus mortel.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Nous d\u00e9montrons que des am\u00e9liorations suppl\u00e9mentaires de LASER ART et CRISPR pour l&#8217;\u00e9dition combinatoire des g\u00e8nes viraux et cellulaires strat\u00e9giquement importants tels que CCR5 chez des souris humanis\u00e9es peuvent \u00eatre r\u00e9alis\u00e9es et servir de preuve de principe pour des investigations ult\u00e9rieures vers des essais cliniques,<\/p>\n\n\n\n<p> ont \u00e9crit les auteurs de l&#8217;\u00e9tude.<\/p>\n<\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>Des chercheurs ont publi\u00e9 une \u00e9tude dans PNAS qui a r\u00e9v\u00e9l\u00e9 qu&#8217;une perc\u00e9e prometteuse dans l&#8217;\u00e9limination du virus de l&#8217;immunod\u00e9ficience humaine de type 1 (VIH-1) chez des souris humanis\u00e9es et infect\u00e9es a \u00e9t\u00e9 r\u00e9alis\u00e9e en combinant deux th\u00e9rapies de modification g\u00e9n\u00e9tique CRISPR avec une th\u00e9rapie antir\u00e9trovirale (ART). Cette approche r\u00e9volutionnaire de traitement pourrait transformer la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":68865,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[684],"tags":[],"class_list":["post-68858","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nouvelles-pharmaceutiques"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/68858","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=68858"}],"version-history":[{"count":6,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/68858\/revisions"}],"predecessor-version":[{"id":68866,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/68858\/revisions\/68866"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media\/68865"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=68858"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=68858"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=68858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}