Bien que ces m\u00e9dicaments soient parfois utilis\u00e9s ensemble, l’utilisation combin\u00e9e est g\u00e9n\u00e9ralement \u00e9vit\u00e9e. Il existe une interaction entre Lipitor (atorvastatine) et l’\u00e9rythromycine. L’association est g\u00e9n\u00e9ralement \u00e9vit\u00e9e en raison du risque accru d’effets secondaires, notamment les effets secondaires rares mais graves de la rhabdomyolyse.<\/p>\n\n\n\n
Cependant, il y aura des cas o\u00f9 les deux pourront \u00eatre combin\u00e9s si cela repr\u00e9sente le meilleur traitement. Veillez \u00e0 en parler \u00e0 votre m\u00e9decin si l’un ou l’autre vous est prescrit.<\/p>\n\n\n\n
Lipitor (atorvastatine) est principalement m\u00e9tabolis\u00e9 dans le foie par le CYP3A4 et la co-administration avec des inhibiteurs du CYP3A4 tels que l’\u00e9rythromycine peut entra\u00eener une augmentation des concentrations plasmatiques et de l’exposition au m\u00e9dicament de l’atorvastatine.<\/p>\n\n\n\n
Des \u00e9tudes cliniques ont montr\u00e9 que l’administration combin\u00e9e de Lipitor et d’\u00e9rythromycine entra\u00eenait une augmentation de 38 % de la concentration sanguine maximale d’atorvastatine. Cela augmente le risque d’effets secondaires tels que les douleurs musculaires, la fatigue et, peut-\u00eatre le plus grave, la rhabdomyolyse.<\/p>\n\n\n\n
D’autres \u00e9tudes ont montr\u00e9 que l’utilisation d’une statine (atorvastatine, simvastatine ou lovastatine) avec l’\u00e9rythromycine \u00e9tait associ\u00e9e \u00e0 un risque plus \u00e9lev\u00e9 d’hospitalisation par rapport \u00e0 un autre antibiotique (azithromycine).<\/p>\n\n\n\n
Bien qu’il y ait certainement un compromis, ces m\u00e9dicaments sont parfois utilis\u00e9s ensemble car l’\u00e9rythromycine n’est g\u00e9n\u00e9ralement utilis\u00e9e que pendant une courte p\u00e9riode. Cependant, dans certains cas, votre m\u00e9decin peut vous demander de rester sous “atorvastatine” jusqu’\u00e0 l’arr\u00eat du traitement par l’\u00e9rythromycine. Il est \u00e9galement possible d’utiliser un autre antibiotique pendant que vous prenez du Lipitor pour \u00e9viter tout contact.<\/p>\n\n\n\n
Si les deux m\u00e9dicaments vous ont \u00e9t\u00e9 prescrits, en particulier par des m\u00e9decins diff\u00e9rents, assurez-vous de les contacter et de voir ce qu’ils vous demandent de faire. En g\u00e9n\u00e9ral, je vois des gens qui soit reportent la prise de Lipitor pendant qu’ils prennent de l’\u00e9rythromycine, soit le m\u00e9decin prescrit un antibiotique diff\u00e9rent.<\/p>\n","protected":false},"excerpt":{"rendered":"
Bien que ces m\u00e9dicaments soient parfois utilis\u00e9s ensemble, l’utilisation combin\u00e9e est g\u00e9n\u00e9ralement \u00e9vit\u00e9e. Il existe une interaction entre Lipitor (atorvastatine) et l’\u00e9rythromycine. L’association est g\u00e9n\u00e9ralement \u00e9vit\u00e9e en raison du risque accru d’effets secondaires, notamment les effets secondaires rares mais graves de la rhabdomyolyse. Cependant, il y aura des cas o\u00f9 les deux pourront \u00eatre combin\u00e9s […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[684],"tags":[],"class_list":["post-68443","post","type-post","status-publish","format-standard","hentry","category-nouvelles-pharmaceutiques"],"_links":{"self":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/68443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/comments?post=68443"}],"version-history":[{"count":2,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/68443\/revisions"}],"predecessor-version":[{"id":68445,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/posts\/68443\/revisions\/68445"}],"wp:attachment":[{"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/media?parent=68443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/categories?post=68443"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pharmacie-vezere.com\/promotions\/wp-json\/wp\/v2\/tags?post=68443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}